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Volume 37 , Issue 5
September/October 2017
Pages e270–e278

Effects of Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting: A Comparative Randomized Controlled Clinical Trial

Mustafa Ozcan, DDS, PhD/Onur Ucak, DDS, PhD/Bahar Alkaya, DDS/Seray Keceli, DDS/Gulsah Seydaoglu, MD, PhD/M. Cenk Haytac, DDS, PhD

PMID: 28817141
DOI: 10.11607/prd.3226

This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing after free gingival graft (FGG) harvesting. A total of 125 patients were randomized after FGG: PRF with butyl-cyanoacrylate (BC) adhesive (PRF group; n = 42), BC adhesive alone (BC group; n = 42), and sterile wet gauze compression (WG group; n = 41). Bleeding, pain, epithelialization, feeding habits, and sensation scores were recorded for different time points. Statistically significant differences were found for all parameters in favor of the PRF group (P = .0001). PRF may provide significant benefits for wound healing parameters and patients’ postoperative course after palatal graft harvesting.

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